In vivo intestinal absorption of 14 C -labelled amino acids, alanine and methionine during P. cyclopium toxicosis in rats

M V LATHA, E R B SHANMUGASUNDARAM

Abstract


Penicillium  cyclopium  is  a  common  food contaminant  and  one such isolate  from  rice  has  been  used in the  present investigation.  Feeding  of  P. cyclopium-contaminated  diet to  rats  is  found  to  affect  the  intestinal  cellular  integrity as shown  bv  histopatholoaical  study,  followed  by analysis  of  major  intestinal  macromolecular constituents.  The in vivo intestinal absorption  studies  wing  '14C  alanine  and  methionine  indicate a  significant  reduction in  the  abrorption  of  these  amino  acids  during  toxicosis and this  is  corroborated  by  the  changes  observed in  the  membrane-bound  enzyme activities which  are  involved  in the  transport.


Keywords


P. cyclopium; toxicity; pathology; in vivo intestinal absorption; cellular constituents; membrane bound enzymes.

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