13C Nuclear Magnetic Resonance Investigations of Neurotransmitter Energetics in Brain

Anant Bahadur Patel, Kamal Saba, Varadarajan K S, Pravin Kumar Mishra


Glutamate and GABA are the major neurotransmitters in a developed brain. Glucose is the major source of energy in the matured brain under normal physiological conditions. 13C NMR spectroscopy has been used to study neuronal glucose oxidation and neuro transmitter cyclefluxes in rats, mice and human brain. These studies indicate that neurotransmitter energetics is supported by oxidative metabolism.

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