A novel approach to decalin synthons of bioactive terpenoids: Inverse electron demand Diels-Alder reactions. and (+/-) - beta- necrodol.

Shreeshailkumar B Hadimani, A Sivaramakrishnan, Sujata V Bhat


A new approach to the synthesis of decalins and tricarbocyclic systems has been achieved through inverse electron demand Diels-Alder reaction.or Na/liq. NH3 or AI- Hg/fHF) affords primary and secondary amines in overall yields of 50-{!4%. (R)-2-Octanol and ethyl L-Iactate were converted via the Mitsunobu procedure to the corresponding chiral amines.cyclic ethers (8). Keywords: Photosensitized electron transfer (PET), episelenonium radical cation, oxyselenylation, a,a' -trans-dialkyl cyclic ethers.been subjected to some kind of chemical or biological examination; thus vast majority of natural wealth remains unexplored. Studies on marine natural products initiated only recently have yielded molecules with exotic molecular architecture and diverse bioactivity. Well-directed research on natural products will enrich our bioresource base. In the current millennium, India is in a pre-eminent position to contribute towards natural product research with the utilization of its rich knowledge base and biodiversity.


Synthesis; bicyclic terpenoids; inverse electron-demand Diels-Alder reaction.reaction.biocatalytic synthesis; chemical ecology; bioremedia- tion.

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